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Analytica chimica acta. 2023 Dec 1:1283:341963. doi: 10.1016/j.aca.2023.341963 Q16.02025

Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films

表面层基质辅助激光解析电离质谱成像技术在药物负载型聚酯尿素膜中的应用 翻译改进

Kayla Williams-Pavlantos  1, Natasha C Brigham-Stinson  2, Matthew L Becker  3, Chrys Wesdemiotis  4

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  • 1 Department of Chemistry, The University of Akron, Akron, OH, 44325, USA.
  • 2 Department of Chemistry, Duke University, Durham, NC, 27708, USA.
  • 3 Department of Chemistry, Duke University, Durham, NC, 27708, USA; Thomas Lord Department of Mechanical Engineering & Materials Science, Duke University, Durham, NC, 27708, USA; Departments of Biomedical Engineering and Orthopedic Surgery, Duke University, Durham, NC, 27708, USA.
  • 4 Department of Chemistry, The University of Akron, Akron, OH, 44325, USA. Electronic address: wesdemiotis@uakron.edu.

    • DOI: 10.1016/j.aca.2023.341963 PMID: 37977787

    摘要 Ai翻译

    Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release over time. Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-MALDI-MSI) is a unique analytical technique that provides an optical representation of chemical composit... ...点击完成人机验证后继续浏览
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    期刊名：Analytica chimica acta

    缩写：ANAL CHIM ACTA

    ISSN：0003-2670

    e-ISSN：1873-4324

    IF/分区：6.0/Q1

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    Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films