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Clinical Trial The Journal of bone and joint surgery. American volume. 2023 Dec 6;105(23):1875-1885. doi: 10.2106/JBJS.23.00223 Q14.32024

Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial

用于儿童肱骨髁上骨折手术治疗后镇痛的研究:一项多中心前瞻性试验的阿片类镇痛与非阿片类镇痛对比结果 翻译改进

Zoe E Belardo  1, Divya Talwar  1, Todd J Blumberg  2, Susan E Nelson  3, Vidyadhar V Upasani  4, Wudbhav N Sankar  1  5, Apurva S Shah  1  5

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作者单位

  • 1 Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • 2 Department of Orthopaedics and Sports Medicine, Seattle Children's Hospital, Seattle, Washington.
  • 3 Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York.
  • 4 Department of Orthopaedics, Rady Children's Hospital, San Diego, California.
  • 5 The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
  • DOI: 10.2106/JBJS.23.00223 PMID: 37956188

    摘要 Ai翻译

    Background: Minimal pain and opioid use after operative treatment for pediatric supracondylar humeral fractures have been previously described; however, opioid-prescribing practices in the United States remain variable. We hypothesized that children without an opioid prescription would report similar postoperative pain compared with children prescribed opioids following closed reduction and percutaneous pinning (CRPP) of supracondylar humeral fractures.

    Methods: Children who were 3 to 12 years of age and were undergoing CRPP for a closed supracondylar humeral fracture were prospectively enrolled in a multicenter, comparative study. Following a standardized dosing protocol, oxycodone, ibuprofen, and acetaminophen were prescribed at 2 hospitals (opioid cohort), and 2 other hospitals prescribed ibuprofen and acetaminophen alone (non-opioid cohort). The children's medication use and the daily pain that they experienced (scored on the Wong-Baker FACES Scale) were recorded at postoperative days 1 to 7, 10, 14, and 21, using validated text-message protocols. Based on an a priori power analysis, at least 64 evaluable subjects were recruited per cohort.

    Results: A total of 157 patients were evaluated (81 [52%] in the opioid cohort and 76 [48%] in the non-opioid cohort). The median age at the time of the surgical procedure was 6.2 years, and 50% of the subjects were male. The mean postoperative pain scores were low overall (<4 of 10), and there were no significant differences in pain ratings between cohorts at any time point. No patient demographic or injury characteristics were correlated with increased pain or medication use. Notably, of the 81 patients in the opioid cohort, 28 (35%) took no oxycodone and 40 (49%) took 1 to 3 total doses across the postoperative period. Patients rarely took opioids after postoperative day 2. A single patient in the non-opioid cohort (1 [1%] of 76) received a rescue prescription of opioids after presenting to the emergency department with postoperative cast discomfort.

    Conclusions: Non-opioid analgesia following CRPP for pediatric supracondylar humeral fractures was equally effective as opioid analgesia. When oxycodone was prescribed, 84% of children took 0 to 3 total doses, and opioid use fell precipitously after postoperative day 2. To improve opioid stewardship, providers and institutions can consider discontinuing the routine prescription of opioids following this procedure.

    Level of evidence: Therapeutic Level II . See Instructions for Authors for a complete description of levels of evidence.

    Keywords:opioid analgesia; non-opioid analgesia; pediatric fractures; operative treatment

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    期刊名:Journal of bone and joint surgery-american volume

    缩写:J BONE JOINT SURG AM

    ISSN:0021-9355

    e-ISSN:1535-1386

    IF/分区:4.3/Q1

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    Opioid Analgesia Compared with Non-Opioid Analgesia After Operative Treatment for Pediatric Supracondylar Humeral Fractures: Results from a Prospective Multicenter Trial