TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
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Metastatic colorectal cancer (mCRC) is characterized by poorer prognosis of patients and limited therapeutic approach, partly due to the lack of effective target. Using mouse models and tumor organoids, this study reported a tripartite motif 21 (TRIM21) protei... ...
