General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants
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Cystic fibrosis (CF) is caused by mutations that compromise the expression and/or function of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. Most people with CF harbor a common misfolded variant (ΔF508) that can be partially ... ...
