Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus
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APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA (cccDNA), ... ...
