Terminal bridging of siRNA duplex at the ribose 2' position controls strand bias and target sequence preference
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Small interfering RNA (siRNA) and short hairpin RNA (shRNA) are widely used as RNA interference (RNAi) reagents. Recently, truncated shRNAs that trigger RNAi in a Dicer-independent manner have been developed. We generated a novel class of RNAi reagent, designa... ...
