MDM2-BCL-XL PROTACs enable degradation of BCL-XL and stabilization of p53
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Inhibition or degradation of anti-apoptotic protein BCL-XL is a viable strategy for cancer treatment. Despite the recent development of PROTACs for degradation of BCL-XL, the E3 ligases are confined to the commonly used VHL and CRBN. Herein we report the devel... ...
