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Myeloid cell leukemia-1: a formidable barrier to anticancer therapeutics and the quest of targeting it

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The antiapoptotic B cell lymphoma-2 (Bcl-2) family members are apical regulators of the intrinsic pathway of apoptosis that orchestrate mitochondrial outer membrane permeabilization (MOMP) through interactions with their proapoptotic counterparts. Overexpressi... ...