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Synthesis of an End-to-End Protein-Glycopolymer Conjugate via Bio-Orthogonal Chemistry

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We report the synthesis of an end-to-end protein-glycopolymer conjugate, namely, site-specific modification of recombinant thrombomodulin at the C-terminus with a chain-end-functionalized glycopolymer. Thrombomodulin (TM) is an endothelial membrane glycoprotei... ...