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Mechanistic Studies on the Synthesis of Pyrrolidines and Piperidines via Copper-Catalyzed Intramolecular C-H Amination

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We have recently developed a method for the synthesis of pyrrolidines and piperidines via intramolecular C-H amination of N-fluoride amides using [Tp x CuL] complexes as precatalysts [Tp x = tris(pyrazolyl)borate ligand and L = THF or CH3CN]. Herein, we report... ...