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LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis

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The regenerative potential of cardiomyocytes in adult mammals is limited. Previous studies reported that cardiomyocyte proliferation is suppressed by AMP-activated protein kinase (AMPK). The role of liver kinase B1 (LKB1), as the major upstream kinase for AMPK... ...