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FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 May;36(5):e22279. doi: 10.1096/fj.202200008R Q14.22025

Ornithine decarboxylase deficiency critically impairs nitrogen metabolism and survival in Aedes aegypti mosquitoes

鸟氨酸脱羧酶缺陷严重影响埃及伊蚊的氮代谢和存活率 翻译改进

Jun Isoe  1, Natthida Petchampai  2, Vena Joseph  2, Patricia Y Scaraffia  2

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作者单位

  • 1 Department of Entomology, The University of Arizona, Tucson, Arizona, USA.
  • 2 Department of Tropical Medicine, Vector-Borne Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
  • DOI: 10.1096/fj.202200008R PMID: 35344219

    摘要 Ai翻译

    Ornithine decarboxylase (ODC; EC 4.1.1.17) catalyzes the conversion of ornithine to putrescine, the rate-limiting first step for de novo polyamine biosynthesis. Previously, we reported that genetic knockdown of xanthine dehydrogenase 1 (XDH1)-a gene encoding the enzyme involved in the last two steps of uric acid synthesis-causes an increase in ODC transcript levels in fat body of blood-fed Aedes aegypti mosquitoes, suggesting a crosstalk at molecular level... ...点击完成人机验证后继续浏览
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    期刊名:Faseb journal

    缩写:FASEB J

    ISSN:0892-6638

    e-ISSN:1530-6860

    IF/分区:4.2/Q1

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    Ornithine decarboxylase deficiency critically impairs nitrogen metabolism and survival in Aedes aegypti mosquitoes