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Engineered EryF hydroxylase improving heterologous polyketide erythronolide B production in Escherichia coli

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In the last two decades, the production of complex polyketides such as erythromycin and its precursor 6-deoxyerythronolide B (6-dEB) was demonstrated feasible in Escherichia coli. Although the heterologous production of polyketide skeleton 6-dEB has reached 21... ...