Predicting Solubility of Newly-Approved Drugs (2016-2020) with a Simple ABSOLV and GSE(Flexible-Acceptor) Consensus Model Outperforming Random Forest Regression
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This study applies the 'Flexible-Acceptor' variant of the General Solubility Equation, GSE(Φ,B), to the prediction of the aqueous intrinsic solubility, log10 S 0, of FDA recently-approved (2016-2020) 'small-molecule' new molecular entities (NMEs). The novel e... ...
