Overcoming glutamate auxotrophy in Escherichia coli itaconate overproducer by the Weimberg pathway
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Biosynthesis of itaconic acid occurs through decarboxylation of the TCA cycle intermediate cis-aconitate. Engineering of efficient itaconate producers often requires elimination of the highly active isocitrate dehydrogenase to conserve cis-aconitate, leading t... ...
