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Balance between Interleukin-18 and Interleukin-18 binding protein in auto-inflammatory diseases

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Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and potent pro-inflammatory activities that are tightly controlled at the level of production and in the extracellular space. Indeed, IL-18 is translated as a leaderless biologica... ...