The cryo-EM structure of the human neurofibromin dimer reveals the molecular basis for neurofibromatosis type 1
{{output}}
Neurofibromin (NF1) mutations cause neurofibromatosis type 1 and drive numerous cancers, including breast and brain tumors. NF1 inhibits cellular proliferation through its guanosine triphosphatase-activating protein (GAP) activity against rat sarcoma (RAS). In... ...
