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α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

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Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-synuclein protein inexorably undergoes extensive ... ...