uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons in vivo
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The eukaryotic 43S pre-initiation complex (PIC) containing Met-tRNAiMet in a ternary complex (TC) with eIF2-GTP scans the mRNA leader for an AUG codon in favorable "Kozak" context. AUG recognition triggers rearrangement of the PIC from an open conformation to ... ...
