Optimization of covalent docking for organophosphates interaction with Anopheles acetylcholinesterase
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Organophosphates (OPs) used as potent insecticides for malaria vector control, covalently phosphorylate the catalytic serine residue of Anopheles gambiae AChE (AgAChE) in a reaction that liberates their leaving groups. In the recent 10-year insecticide use ass... ...