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Radiography (London, England : 1995). 2022 Feb;28(1):95-101. doi: 10.1016/j.radi.2021.08.006 Q22.82025

Amide proton transfer-weighted MRI in the clinical setting - correlation with dynamic susceptibility contrast perfusion in the post-treatment imaging of adult glioma patients at 3T

用于成人胶质瘤治疗后评估的胺基氢传递加权MRI的临床应用及其与3T动态对比增强灌注成像的相关性研究 翻译改进

A I Friismose  1, L Markovic  2, N Nguyen  2, O Gerke  3, M K Schulz  4, B R Mussmann  5

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作者单位

  • 1 Radiology Department, Odense University Hospital, Odense, Denmark. Electronic address: Ancuta.Ioana.Friismose@rsyd.dk.
  • 2 Radiology Department, Odense University Hospital, Odense, Denmark.
  • 3 Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  • 4 Department of Neurosurgery, Odense University Hospital, Odense, Denmark.
  • 5 Radiology Department, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, Denmark; OPEN, Odense Patient Data Exploratory Network, Odense University Hospital, Odense, Denmark; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway.

    • DOI: 10.1016/j.radi.2021.08.006 PMID: 34509365

    摘要 Ai翻译

    Introduction: We investigated the correlation between amide proton transfer-weighted magnetic resonance imaging (APTw MRI) and dynamic susceptibility contrast (DSC) perfusion in order to assess the potential of APTw MRI as an alternative to DSC in adult brain tumor (glioma) imaging.

    Methods: After Ethical Committee approval, forty adult patients, treated for histopathologically confirmed glioma (World Health Organization (WHO) grade II-IV), were prospectively imaged at 3 Tesla (3 T) with DSC perfusion and a commercially available three-dimensional (3D) APTw sequence. Two consultant neuroradiologists independently performed region of interest (ROI) measurements on relative cerebral blood volume (rCBV) and APTw maps, co-registered with anatomical images. The correlation APTw MRI-DSC perfusion was assessed using Spearman's rank-order test. Inter-observer agreement was evaluated by the intraclass correlation coefficient (ICC) and Bland-Altman (BA) plots.

    Results: A statistically significant moderately strong positive correlation was observed between maximum rCBV (rCBVmax) and maximum APTw (APTwmax) values (observer 1: r = 0.73; p < 0.01; observer 2: r = 0.62; p < 0.01). We found good inter-observer agreement for APTwmax (ICC = 0.82; 95% confidence interval (CI) 0.66-0.90), with somewhat broad outer 95% CI for the BA Limits of Agreement (LoA) (-1.6 to 1.9). ICC for APTwmax was higher than ICC for rCBVmax (ICC = 0.74; 95%; CI 0.50-0.86), but the difference was not statistically significant.

    Conclusion: APTwmax values correlate positively with rCBVmax in patients treated for brain glioma. APTw imaging is a reproducible technique, with some observer dependence. Results need to be confirmed by a larger population analysis.

    Implications for practice: APTw MRI can be a useful addition to glioma follow-up imaging and a potential alternative to DSC perfusion, especially in patients where contrast agent is contraindicated.

    Keywords: Amides; Brain neoplasms; Cerebral blood volume; Glioma; Magnetic resonance imaging; Perfusion.

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    Copyright © Radiography (London, England : 1995). 中文内容为AI机器翻译，仅供参考！

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    期刊名：Radiography

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    ISSN：1078-8174

    e-ISSN：1532-2831

    IF/分区：2.8/Q2

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    Amide proton transfer-weighted MRI in the clinical setting - correlation with dynamic susceptibility contrast perfusion in the post-treatment imaging of adult glioma patients at 3T