A proline metabolism selection system and its application to the engineering of lipid biosynthesis in Chinese hamster ovary cells
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Chinese hamster ovary (CHO) cells are the leading mammalian cell host employed to produce complex secreted recombinant biotherapeutics such as monoclonal antibodies (mAbs). Metabolic selection marker technologies (e.g. glutamine synthetase (GS) or dihydrofolat... ...
