Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention
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We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) selects for mutatio... ...
