PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys
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Mutations of PTEN-induced kinase I (PINK1) cause early-onset Parkinson's disease (PD) with selective neurodegeneration in humans. However, current PINK1 knockout mouse and pig models are unable to recapitulate the typical neurodegenerative phenotypes observed ... ...
