Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation
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With the discovery of PROteolysis TArgeting Chimeras (PROTACs) twenty years ago, targeted protein degradation (TPD) has changed the landscape of drug development. PROTACs have evolved from cell-impermeable peptide-small molecule chimeras to orally bioavailable... ...
