NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (G... ...
