A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis
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Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 (mTORC1... ...
