Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase
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Thermal motions of enzymes have been invoked to explain the temperature dependence of kinetic isotope effects (KIE) in enzyme-catalyzed hydride transfers. Formate dehydrogenase (FDH) from Candida boidinii exhibits a temperature independent KIE that becomes tem... ...
