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European journal of medicinal chemistry. 2021 Aug 5:220:113436. doi: 10.1016/j.ejmech.2021.113436 Q15.92025

A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp

一种抗多重耐药铜绿假单胞菌、肺炎克雷伯氏菌和不动杆菌属的γ-内酰胺类色氨酸抗生素 翻译改进

Joel A Goldberg  1, Vijay Kumar  2, Elizabeth J Spencer  3, Denton Hoyer  3, Steven H Marshall  1, Andrea M Hujer  4, Kristine M Hujer  4, Christopher R Bethel  1, Krisztina M Papp-Wallace  5, Federico Perez  6, Michael R Jacobs  7, David van Duin  8, Barry N Kreiswirth  9, Focco van den Akker  10, Mark S Plummer  11, Robert A Bonomo  12

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作者单位

  • 1 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
  • 2 Department of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • 3 Yale Center for Molecular Discovery, West Haven, CT, 06516, USA.
  • 4 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • 5 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • 6 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA; Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
  • 7 Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Pathology, University Hospitals Cleveland Medical Center, Division of Clinical Microbiology, Cleveland, OH, 44106, USA.
  • 8 University of North Carolina School of Medicine, Chapel Hill, NC, 27514, USA.
  • 9 Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, 07601, USA.
  • 10 Department of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address: fxv5@case.edu.
  • 11 Yale Center for Molecular Discovery, West Haven, CT, 06516, USA. Electronic address: marksplummer@gmail.com.
  • 12 Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA; Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Departments of Pharmacology, Molecular Biology & Microbiology, And Proteomics & Bioinformatics, Case Western Reserve University, Cleveland, OH, 44106, USA; CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology (Case VA CARES), Cleveland, OH, 44106, USA. Electronic address: Robert.Bonomo@va.gov.

    • DOI: 10.1016/j.ejmech.2021.113436 PMID: 33933754

    摘要 Ai翻译

    Serious infections caused by multidrug-resistant (MDR) organisms (Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii) present a critical need for innovative drug development. Herein, we describe the preclinical evaluation of YU253911, 2, a novel γ-lactam siderophore antibiotic with potent antimicrobial activity against MDR Gram-negative pathogens. Penicillin-binding protein (PBP) 3 was shown to be a target of 2 using a binding assay wi... ...点击完成人机验证后继续浏览
    Copyright © European journal of medicinal chemistry. 中文内容为AI机器翻译，仅供参考！

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    期刊名：European journal of medicinal chemistry

    缩写：EUR J MED CHEM

    ISSN：0223-5234

    e-ISSN：1768-3254

    IF/分区：5.9/Q1

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    A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp