Protein quality control degron-containing substrates are differentially targeted in the cytoplasm and nucleus by ubiquitin ligases
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Intracellular proteolysis by the ubiquitin-proteasome system regulates numerous processes and contributes to protein quality control (PQC) in all eukaryotes. Covalent attachment of ubiquitin to other proteins is specified by the many ubiquitin ligases (E3s) ex... ...
