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Efficient inhibition of O-glycan biosynthesis using the hexosamine analog Ac5GalNTGc

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There is a critical need to develop small-molecule inhibitors of mucin-type O-linked glycosylation. The best-known reagent currently is benzyl-GalNAc, but it is effective only at millimolar concentrations. This article demonstrates that Ac5GalNTGc, a peracetyl... ...