Disruption of asparagine-linked glycosylation to rescue and alter gating of the NaV1.5-Na+ channel
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SCN5A gene encodes the voltage-gated sodium channel NaV1.5 which is composed of a pore-forming α subunit of the channel. Asparagine (N)-linked glycosylation is one of the common post-translational modifications in proteins. The aim of this study was to invest... ...
