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ACS combinatorial science. 2020 Dec 14;22(12):712-733. doi: 10.1021/acscombsci.0c00179 Q20.02024

Expanding the Chemical Diversity of Genetically Encoded Libraries

扩展遗传编码库的化学多样性 翻译改进

Sabrina E Iskandar  1, Victoria A Haberman  1, Albert A Bowers  1  2  3

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作者单位

  • 1 Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
  • 2 Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
  • 3 Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
  • DOI: 10.1021/acscombsci.0c00179 PMID: 33167616

    摘要 Ai翻译

    The power of ribosomes has increasingly been harnessed for the synthesis and selection of molecular libraries. Technologies, such as phage display, yeast display, and mRNA display, effectively couple genotype to phenotype for the molecular evolution of high affinity epitopes for many therapeutic targets. Genetic code expansion is central to the success of these technologies, allowing researchers to surpass the intrinsic capabilities of the ribosome and access new, genetically encoded materials for these selections. Here, we review techniques for the chemical expansion of genetically encoded libraries, their abilities and limits, and opportunities for further development. Importantly, we also discuss methods and metrics used to assess the efficiency of modification and library diversity with these new techniques.

    Keywords: chemical modification; display technologies; genetically encoded libraries; peptide libraries; quality control metrics; unnatural amino acids.

    Keywords:genetically encoded libraries; chemical diversity

    Copyright © ACS combinatorial science. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Acs combinatorial science

    缩写:ACS COMB SCI

    ISSN:2156-8952

    e-ISSN:2156-8944

    IF/分区:0.0/Q2

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    Expanding the Chemical Diversity of Genetically Encoded Libraries