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Journal of clinical medicine. 2020 Sep 11;9(9):2936. doi: 10.3390/jcm9092936 Q12.92025

The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery

巨噬细胞迁移抑制因子(MIF)启动子多态性(rs3063368, rs755622)可预测心脏手术后的急性肾损伤和死亡率 翻译改进

Luisa Averdunk  1  2, Jürgen Bernhagen  3  4  5, Karl Fehnle  6, Harald Surowy  2, Hermann-Josef Lüdecke  2, Sören Mucha  7  8, Patrick Meybohm  9, Dagmar Wieczorek  2, Lin Leng  10, Gernot Marx  1, David E Leaf  11  12, Alexander Zarbock  13, Kai Zacharowski  9, On Behalf Of The RIPHeart Study Collaborators, Richard Bucala  10, Christian Stoppe  1  14

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作者单位

  • 1 Department of Intensive Care Medicine, University Hospital Aachen, Rheinisch Westphälische Technische Hochschule Aachen, 52074 Aachen, Germany.
  • 2 Institute of Human Genetics and Department of Pediatrics, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
  • 3 Department of Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, 80333 Munich, Germany.
  • 4 German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 10785 Berlin, Germany.
  • 5 Munich Cluster for Systems Neurology (EXC 2145 SyNergy), 81377 Munich, Germany.
  • 6 Algora: Statistics and Clinical Research GmbH, 85540 Haar, Germany.
  • 7 Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, 24118 Kiel, Germany.
  • 8 Institute for Cardiogenetics, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany.
  • 9 Department of Anesthesiology, Intensive Care Medicine & Pain Therapy, University Hospital Frankfurt, Goethe University, 60323 Frankfurt, Germany.
  • 10 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
  • 11 Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • 12 Harvard Medical School, Boston, MA 02115, USA.
  • 13 Intensive Care and Pain Medicine, Department of Anesthesiology, University of Münster, 48149 Münster, Germany.
  • 14 Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Würzburg, 97080 Würzburg, Germany.

    • DOI: 10.3390/jcm9092936 PMID: 32932965

    摘要 Ai翻译

    Background: Macrophage Migration Inhibitory Factor (MIF) is highly elevated after cardiac surgery and impacts the postoperative inflammation. The aim of this study was to analyze whether the polymorphisms CATT5-7 (rs5844572/rs3063368,"-794") and G>C single-nucleotide polymorphism (rs755622,-173) in the MIF gene promoter are related to postoperative outcome. Me... ...点击完成人机验证后继续浏览
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    期刊名：Journal of clinical medicine

    缩写：J CLIN MED

    ISSN：N/A

    e-ISSN：2077-0383

    IF/分区：2.9/Q1

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    The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery