Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System
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The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chemically tuneable AdPRO... ...
