Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets
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Ribonucleotide reductases (RNRs) catalyze the de novo conversion of nucleotides to deoxynucleotides in all organisms, controlling their relative ratios and abundance. In doing so, they play an important role in fidelity of DNA replication and repair. RNRs' cen... ...