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Scientific reports. 2020 Jun 8;10(1):9209. doi: 10.1038/s41598-020-65836-x Q13.92025

Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating

皮层M₁胆碱能受体激活及其相关胞内信号转导是物体记忆更新的必要条件 翻译改进

Kristen H Jardine  1, Cassidy E Wideman  1, Chelsea MacGregor  1, Cassandra Sgarbossa  1, Dean Orr  1, Krista A Mitchnick  1, Boyer D Winters  2

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  • 1 Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
  • 2 Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. bwinters@uoguelph.ca.

    • DOI: 10.1038/s41598-020-65836-x PMID: 32514039

    摘要 Ai翻译

    Reactivated long-term memories can become labile and sensitive to modification. Memories in this destabilized state can be weakened or strengthened, but there is limited research characterizing the mechanisms underlying retrieval-induced qualitative updates (i.e., information integration). We have previously implicated cholinergic transmission in object memory destabilization. Here we present a novel rodent paradigm developed to assess the role of this cho... ...点击完成人机验证后继续浏览
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    期刊名：Scientific reports

    缩写：SCI REP-UK

    ISSN：2045-2322

    e-ISSN：2045-2322

    IF/分区：3.9/Q1

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    Activation of cortical M1 muscarinic receptors and related intracellular signaling is necessary for reactivation-induced object memory updating