EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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Deregulation of the PRC2 complex, comprised of the core subunits EZH2, SUZ12, and EED, drives aberrant hypermethylation of H3K27 and tumorigenicity of many cancers. Although inhibitors of EZH2 have shown promising clinical activity, preclinical data suggest th... ...
