Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation
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The transcription factor NRF2 confers cellular protection by maintaining cellular redox homeostasis and proteostasis. Basal NRF2 levels are normally low due to KEAP1-mediated ubiquitylation and subsequent proteasomal degradation. KEAP1, a substrate adaptor pro... ...
