Checkpoint inhibition of PD-L1 and CTLA-4 in a child with refractory acute leukemia
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Children with multiple relapsed or refractory leukemia have dismal survival. Research has identified engagement of immune checkpoint receptors (e.g., PD-1, PD-L1 and CTLA-4) as a mechanism for treatment resistance. For adult cancer, inhibitors of PD-1 (nivolum... ...
