Artificial Restriction DNA Cutter Using Nuclease S1 for Site-Selective Scission of Genomic DNA
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By combining a pair of pseudo-complementary peptide nucleic acids (pcPNAs) with S1 nuclease, a novel tool to cut DNA at a predetermined site can be obtained. Complementary pcPNAs invade the DNA duplex and base pair to each strand of a target site, creating sin... ...
