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Effect of Osmolality on the Pharmacokinetic Interaction between Apple Juice and Atenolol in Rats

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A recent clinical study reported that the ingestion of apple juice (AJ) markedly reduced the plasma concentration of atenolol; however, our in vitro study showed that atenolol may not be a substrate of organic anion transporting polypeptide 2B1 (OATP2B1), so t... ...