Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations
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Aim: Resistance to fluoropyrimidine drugs (FPs) is a major cause of mortality in colorectal cancer (CRC). We assessed the potency advantage of the polymeric FP F10 relative to 5-fluorouracil (5FU) in four human CRC cell lines tha... ...
