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Journal of colloid and interface science. 2019 Mar 7:538:630-637. doi: 10.1016/j.jcis.2018.12.032 Q19.72024

Intercellular adhesion molecule 1 antibody-mediated mesoporous drug delivery system for targeted treatment of triple-negative breast cancer

针对三阴性乳腺癌的细胞间粘附分子1抗体介导的介观多孔药物递送系统 翻译改进

Mengru Wang  1, Wanhua Liu  2, Yanqiu Zhang  3, Meng Dang  4, Yunlei Zhang  5, Jun Tao  4, Kun Chen  4, Xin Peng  1, Zhaogang Teng  6

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作者单位

  • 1 Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009 Jiangsu, PR China.
  • 2 Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009 Jiangsu, PR China. Electronic address: liuwanhua.com@126.com.
  • 3 Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Nanjing 210002, Jiangsu, PR China.
  • 4 Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046 Jiangsu, PR China.
  • 5 Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002 Jiangsu, PR China.
  • 6 Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, 210002 Jiangsu, PR China; State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 Jiangsu, PR China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications, Nanjing 210046 Jiangsu, PR China. Electronic address: tzg@fudan.edu.cn.

    • DOI: 10.1016/j.jcis.2018.12.032 PMID: 30554096

    摘要 Ai翻译

    The development of effective targeted therapies for triple negative breast cancer (TNBC) remains a challenge. This targeted drug delivery system used a near-infrared fluorescence dye cyanine 5.5 (Cy5.5) and an ICAM-1 antibody on thioether-bridged periodic mesoporous organosilica nanoparticles (PMOs). The ICAM-1 antibody and cyanine 5.5-engineered PMOs (PMO-Cy5.5-ICAM) offer excellent in vivo and in vitro biocompatibility. The PMO-Cy5.5-ICAM shows a loading capacity up to 400 mg/g of doxorubicin (DOX). The drug release profile of the DOX-loaded targeted delivery system (DOX@PMO-Cy5.5-ICAM) is pH-sensitive. Confocal microscopy showed that the PMO-Cy5.5-ICAM efficiently targets and enters TNBC cells. In in vivo experiments, the DOX@PMO-Cy5.5-ICAM accumulates more in TNBCs than in the control groups and exhibits better therapeutic effects on TNBC; thus, it is a promising treatment strategy for TNBC.

    Keywords: Drug delivery system; ICAM-1; Periodic mesoporous organosilica; Targeted therapy; Triple-negative breast cancer.

    Keywords：triple-negative breast cancer

    关键词：细胞间黏附分子1抗体; 介孔药物输送系统; 三阴性乳腺癌

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    期刊名：Journal of colloid and interface science

    缩写：J COLLOID INTERF SCI

    ISSN：0021-9797

    e-ISSN：1095-7103

    IF/分区：9.7/Q1

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    Intercellular adhesion molecule 1 antibody-mediated mesoporous drug delivery system for targeted treatment of triple-negative breast cancer