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Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016

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Background: Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role in defining the antigenic ... ...