Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer
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Overexpression and cellular mis-localization of aurora kinase A (AURKA) in gastrointestinal cancers results in chromosomal instability, activation of multiple oncogenic pathways, and inhibition of pro-apoptotic signaling. Inhibition of AURKA causes mitotic del... ...
