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Biological psychiatry. 2017 Oct 1;82(7):488-499. doi: 10.1016/j.biopsych.2017.03.002 Q19.02025

Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety

调节焦虑的两大经典内源大麻素信号系统间的功能冗余性 翻译改进

Gaurav Bedse  1, Nolan D Hartley  2, Emily Neale  1, Andrew D Gaulden  1, Toni A Patrick  1, Philip J Kingsley  3, Md Jashim Uddin  3, Niels Plath  4, Lawrence J Marnett  3, Sachin Patel  5

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  • 1 Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
  • 2 Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • 3 Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Chemistry, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Vanderbilt University School of Medicine, Nashville, Tennessee; Department of Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.
  • 4 Department of H. Lundbeck A/S, Copenhagen, Denmark.
  • 5 Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee. Electronic address: sachin.patel@vanderbilt.edu.
  • DOI: 10.1016/j.biopsych.2017.03.002 PMID: 28438413

    摘要 Ai翻译

    Background: Increasing the available repertoire of effective treatments for mood and anxiety disorders represents a critical unmet need. Pharmacological augmentation of endogenous cannabinoid (eCB) signaling has been suggested to represent a novel approach to the treatment of anxiety disorders; however, the functional interactions between two canonical eCB pathways mediated via anandamide (N-arachidonylethanolamine [AEA]) and... ...点击完成人机验证后继续浏览
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    期刊名:Biological psychiatry

    缩写:BIOL PSYCHIAT

    ISSN:0006-3223

    e-ISSN:1873-2402

    IF/分区:9.0/Q1

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    Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety