Identification of Potential Helicoverpa armigera (Lepidoptera: Noctuidae) Sterol Carrier Protein-2 Inhibitors Through High-Throughput Virtual Screening
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Helicoverpa armigera sterol carrier protein-2 (HaSCP-2) is a validated target for development of novel insecticides due to its divergent protein structure and function from the vertebrate SCP-2. HaSCP-2 is important for normal development and fertility in Helicoverpa armigera (Hübner). The discovery of chemical inhibitors of HaSCP-2 through a structure-based virtual screening is reported here. Bioassay indicated that H1 and H14 had inhibitory effect on th... ...
