Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy
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The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). MMR defects are well known to be as... ...
