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Clinical Trial The lancet. HIV. 2017 Dec;4(12):e536-e546. doi: 10.1016/S2352-3018(17)30095-4 Q113.02025

Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study

一项在先前未接受过治疗的感染HIV-1女性中比较多替拉韦、阿巴卡韦和拉米夫定与阿扎那韦/利托那韦增强剂联合恩曲他滨和富马酸替诺福韦二吡呋酯疗效的随机开放性非劣效性3b期研究(ARIA):第48周结果 翻译改进

Catherine Orrell  1, Debbie P Hagins  2, Elena Belonosova  3, Norma Porteiro  4, Sharon Walmsley  5, Vicenç Falcó  6, Choy Y Man  7, Alicia Aylott  8, Ann M Buchanan  7, Brian Wynne  9, Cindy Vavro  7, Michael Aboud  10, Kimberly Y Smith  7; ARIA study team

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作者单位

  • 1 Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa. Electronic address: catherine.orrell@hiv-research.org.za.
  • 2 Chatham County Health Department, Savannah, GA, USA.
  • 3 Orel Regional Center for AIDS, Orel, Russia.
  • 4 Fundación IDEAA, Buenos Aires, Argentina.
  • 5 University Health Network, Toronto, ON, Canada.
  • 6 Hospital Vall d'Hebron, Barcelona, Spain.
  • 7 ViiV Healthcare, Research Triangle Park, NC, USA.
  • 8 GlaxoSmithKline, Stockley Park, UK.
  • 9 ViiV Healthcare, Collegeville, PA, USA.
  • 10 ViiV Healthcare, Brentford, UK.
  • DOI: 10.1016/S2352-3018(17)30095-4 PMID: 28729158

    摘要 Ai翻译

    Background: Dolutegravir is a once-daily integrase strand transfer inhibitor with no need for pharmacokinetic boosting that is approved for the treatment of HIV-1 infection. Because women are often under-represented in HIV clinical trials, we addressed the safety and efficacy of dolutegravir in women with HIV-1. Methods: The ARIA study is a ... ...点击完成人机验证后继续浏览
    Copyright © The lancet. HIV. 中文内容为AI机器翻译,仅供参考!

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    期刊名:Lancet hiv

    缩写:LANCET HIV

    ISSN:2352-3018

    e-ISSN:2352-3018

    IF/分区:13.0/Q1

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    Fixed-dose combination dolutegravir, abacavir, and lamivudine versus ritonavir-boosted atazanavir plus tenofovir disoproxil fumarate and emtricitabine in previously untreated women with HIV-1 infection (ARIA): week 48 results from a randomised, open-label, non-inferiority, phase 3b study